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२४ घंटे के व्रत से उम्र संबंधी गैस्ट्रो-इनेस्टिनल और कैंसर की रोकथाम संभव

अमेरिकन संस्था MIT के वैज्ञानिकों ने प्रसिद्ध  शोध पत्रिका “सेल स्टेम सेल” में प्रकाशित अपने शोध में व्रत रखने के वैज्ञानिक लाभों को दर्शाया जो सदियों पुरानी भारतीय व्रत परंपरा  के दूरगामी फायदों की पुष्टि करते हैं | स्टेम कोशिकाएं हम सबके शरीर का महत्वपूर्ण हिस्सा होती हैं, जो विभिन्न अंगो की कोशिकाओं का पुनर्निमाण करती रहती हैं और उनके क्षय को बचाती हैं पर उम्र बढ़ने के साथ उनकी इस क्षमता में कमी आने लगती है जो हमे तमाम बीमारियां का शिकार बनती है। आंत की स्टेम कोशिकाएं भी उम्र बढ़ने के साथ अपनी पुनरुद्ध्भवन या पुनर्निमाण क्षमता धीरे धीरे खोने लगती हैं, जिससे उम्र दराज लोगों की गैस्ट्रो-इनेस्टिनल या अन्य आंत सम्बन्धी बिमारियों जैसे कैंसर इत्यादि से लड़ने की क्षमता कम होती जाती है। अब  वैज्ञानिकों के ग्रुप ने चूहों पर किये प्रयोगों से ये सिद्ध किया है की २४ घंटों का व्रत रखने से आंत की विशिष्ट स्टेम कोशिकाओं की पूनरुद्ध्भवन क्षमता फिर से वापस पायी जा सकती है।

व्रत रखने से उम्र दराज और नवजवान दोनों ग्रुप के चूहों के स्टेम कोशाओं की पुनर्निर्माण क्षमता में आश्चर्यजनक वृद्धि देखी गयी। दरअसल ऐसी स्टेम कोशायें जिन्हे २४ घंटों तक कुछ खाद्य पदार्थ नहीं दिया गया, वे कोशायें ग्लूकोस की बजाये वसीय अम्लों को घटकों में तोड़ने लगीं, जिससे उनकी पुनर्निमाण क्षमता ज्यादा बढ़ गयी।  वैज्ञानिकों ने उम्मीद जताई है की इस तरह का शोध आने वाले समय में उम्र दराज लोग जो गैस्ट्रो-इनेस्टिनल से पीड़ित हैं या जो कैंसर संबंधी कीमोथेरेपी ले रहे हैं, उन लोगों के लिए खास फायदेमंद साबित हो सकती है।




Evolving gene responsible for alcohol digestion may stop Humans from drinking alcohol

A new study by University of Pennsylvania researchers investigating recent signals of positive selection of genes across human populations reveals the concurrent emergence of alcohol dehydrogenase (ADH) gene variant in various populations across the globe without direct genetic heritage. The study has been published in the journal Nature, Ecology & Evolution utilized the 1000 Genome Project data and analyzed 2500 individuals from 20  populations across four continents.

ADH is a group of enzymes normally present in humans to break down the alcohol. But the emergent gene variant of the ADH increases enzyme activity resulting into the less effective breaking down of the alcohol consequently, leading to adverse physical response to alcohol consumption.

People with this specific genetic variant may feel sick after drinking alcohol and henceforth, are unlikely to develop a taste for alcohol or become alcoholic.


New Study found Promising Compounds to cure Whipworm infection

Good news is here for around 500 million people of mostly developing countries who gets infected with the human whipworm, a potent physical and mental growth damager, now they can be hopeful for effective treatment in coming days as a new finding shows that the whipworm is killed at egg and adult stage by a new drug developed by the team from the three UK universities, Oxford, Manchester and University College London.

Currently there are no vaccines available for human whipworm and treatments are based on ages old drugs having low success rate. The team of researchers studies a class of dihydrobenzoxazepinonesm, which had never been related to regulating whipworms, found the compounds a more effective killer of the adult stages of whipworm than present drugs. Not only that, even whipworm eggs are also affected which are contagious and passed from infected faeces into healthy people by hand to mouth contact, quite often in areas where people live close together or areas with unsanitary toilets.

Generally, the whipworm eggs are highly resistant to UV radiation, extreme temperature changes and may remain viable for longer, however the newly studied compounds which are effective against the eggs could be used as a spray to stop whipworm infection at source itself.


Frederick A. Partridge, Emma A. Murphy, Nicky J. Willis, Carole J. R. Bataille, Ruth Forman, Narinder Heyer-Chauhan, Bruno Marinič, Daniel J. C. Sowood, Graham M. Wynne, Kathryn J. Else, Angela J. Russell, David B. Sattelle. Dihydrobenz[e][1,4] oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivoPLOS Neglected Tropical Diseases, 2017; 11 (2): e0005359 DOI: 10.1371/journal.pntd.0005359



MERS could be curable..Antibody against MERS found by Scientists


A team of Scientists have recognized a protein that worn out the MERS virus, giving the hope for a potential relief to prevent and treat the incurable disease, according to a report published in Proceedings of the National Academy of Sciences on 27th July. Middle East Respiratory Syndrome (MERS) is an exceptionally lethal pulmonary infection instigated by a formerly unidentified coronavirus (CoV), possibly passed on to humans by infected camels. There is no licensed vaccine or antiviral available so far to treat MERS, which causes symptoms such as fever, cough and shortness of breath. The team isolated a potent MERS-CoV-neutralizing antibody, named LCA60, from memory B cells of an infected patient. LCA60 antibody binds to a novel site on the spike protein and effectively nullifies infection of MERS by meddling with the binding to the cellular receptor CD26. Scientists claim that LCA60 antibody can efficiently be used for prophylaxis, for postexposure prophylaxis of individuals at risk, or for the treatment of human cases of MERS infection. Notably, LCA60, when given to infected mice, dramatically reduced the amount of the MERS virus in the lungs within days. Even in the worst-case scenario, only one virus remained after three days for every 100 viruses at the start of the treatment. In most cases, the virus became untraceable within five days of treatment. The antibody fought the virus whether it was given a day before or a day after the mice were infected. Current MERS outbreak in China and South Korea has caused 186 infections and 36 deaths as of 28th July WHO report.

See in details;

D. Corti et al. Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus. PNAS. Published online July 27, 2015. doi: 10.1073/pnas.151019912

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