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२४ घंटे के व्रत से उम्र संबंधी गैस्ट्रो-इनेस्टिनल और कैंसर की रोकथाम संभव

अमेरिकन संस्था MIT के वैज्ञानिकों ने प्रसिद्ध  शोध पत्रिका “सेल स्टेम सेल” में प्रकाशित अपने शोध में व्रत रखने के वैज्ञानिक लाभों को दर्शाया जो सदियों पुरानी भारतीय व्रत परंपरा  के दूरगामी फायदों की पुष्टि करते हैं | स्टेम कोशिकाएं हम सबके शरीर का महत्वपूर्ण हिस्सा होती हैं, जो विभिन्न अंगो की कोशिकाओं का पुनर्निमाण करती रहती हैं और उनके क्षय को बचाती हैं पर उम्र बढ़ने के साथ उनकी इस क्षमता में कमी आने लगती है जो हमे तमाम बीमारियां का शिकार बनती है। आंत की स्टेम कोशिकाएं भी उम्र बढ़ने के साथ अपनी पुनरुद्ध्भवन या पुनर्निमाण क्षमता धीरे धीरे खोने लगती हैं, जिससे उम्र दराज लोगों की गैस्ट्रो-इनेस्टिनल या अन्य आंत सम्बन्धी बिमारियों जैसे कैंसर इत्यादि से लड़ने की क्षमता कम होती जाती है। अब  वैज्ञानिकों के ग्रुप ने चूहों पर किये प्रयोगों से ये सिद्ध किया है की २४ घंटों का व्रत रखने से आंत की विशिष्ट स्टेम कोशिकाओं की पूनरुद्ध्भवन क्षमता फिर से वापस पायी जा सकती है।

व्रत रखने से उम्र दराज और नवजवान दोनों ग्रुप के चूहों के स्टेम कोशाओं की पुनर्निर्माण क्षमता में आश्चर्यजनक वृद्धि देखी गयी। दरअसल ऐसी स्टेम कोशायें जिन्हे २४ घंटों तक कुछ खाद्य पदार्थ नहीं दिया गया, वे कोशायें ग्लूकोस की बजाये वसीय अम्लों को घटकों में तोड़ने लगीं, जिससे उनकी पुनर्निमाण क्षमता ज्यादा बढ़ गयी।  वैज्ञानिकों ने उम्मीद जताई है की इस तरह का शोध आने वाले समय में उम्र दराज लोग जो गैस्ट्रो-इनेस्टिनल से पीड़ित हैं या जो कैंसर संबंधी कीमोथेरेपी ले रहे हैं, उन लोगों के लिए खास फायदेमंद साबित हो सकती है।

https://www.sciencedaily.com/releases/2018/05/180503142852.htm

 

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Evolving gene responsible for alcohol digestion may stop Humans from drinking alcohol

A new study by University of Pennsylvania researchers investigating recent signals of positive selection of genes across human populations reveals the concurrent emergence of alcohol dehydrogenase (ADH) gene variant in various populations across the globe without direct genetic heritage. The study has been published in the journal Nature, Ecology & Evolution utilized the 1000 Genome Project data and analyzed 2500 individuals from 20  populations across four continents.

ADH is a group of enzymes normally present in humans to break down the alcohol. But the emergent gene variant of the ADH increases enzyme activity resulting into the less effective breaking down of the alcohol consequently, leading to adverse physical response to alcohol consumption.

People with this specific genetic variant may feel sick after drinking alcohol and henceforth, are unlikely to develop a taste for alcohol or become alcoholic.

 

Killing Caner with Genetically modified Bacteria

Researchers employ a genetically modified bacteria to eliminate tumors in mice.

The report published in February issue of the Science Translational Medicine discloses an immunological mechanism that contributes to bacteria-driven, cancer–killing activity claiming that a genetically altered Salmonella typhimurium a gastroenteritis-causing bacteria, is an effective destroyer of mouse tumors.

The reasoning behind most bacteria-driven cancer therapies is the fact that oxygen-starved and necrotic cores of tumors are attractive environments for anaerobic bacteria such as Salmonella, Clostridium, and Listeria, and an infection can lead to tumor colonization by these bugs. By means of active multiplication, the bacteria can directly kill the cancer cells and also attract the attention of the body’s immune system (which is generally suppressed within tumors), leading to further tumor destruction.

Things are not so easy and there are safety issues in implementation for patients. In a recent trial, researchers found attenuated Salmonella bacteria to be safe, but they were unable to create a strong response. To overcome the issue researchers tried to boost the potency of the Salmonella by engineering the bacteria to overexpress a protein proven to induce a strong immune response—flagellin B. As per the new report, intravenous injections of the flagellin expressing Salmonella eliminated the experimental tumors in 55 percent of mice, which then remained healthy until the end of the four-month observation period. Without overexpression of flagellin, the tumors in the mice tended to regrow after initial shrinking by the Salmonella. 

Some scientist agrees that current study extends our understanding of bacterial-based cancer therapy at a molecular level but one of the problems with developing bacterial cancer treatments has been that “these bacteria are almost a black box.” They promote cancer destruction, but no one is exactly sure how.

Source: J.H. Zheng et al., “Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin,” Science Translational Medicine, 9, eaak9537, 2017.

Take Vitamin D regularly to keep away from Respiratory Diseases

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Next time if you suffer with acute respiratory infections, don’t ignore your Vitamin D status which plays a significantly effective role in prevention from respiratory diseases, claimed by a new research paper published online in journal the BMJ. The study confirms that daily or weekly vitamin D supplements had the utmost advantage for individuals with the maximum noteworthy vitamin D deficiency.

Generally, people comprehend that vitamin D is critical for bone and muscle health but this new research found that it also helps the body fight acute respiratory infection, which is accountable for millions of deaths globally each year. The new research is a global collaborative study comprising a participant data meta-analysis of 25 randomized controlled trials including >11,000 participants.

Many observational studies have already established the association of low vitamin D levels with greater vulnerability to acute respiratory infections, based on long time follow up of participants without providing a specific treatment. There have been discrepancies in clinical trials conducted to investigate the protective ability of vitamin D supplementation.

The new study resolves these inconsistencies and the researchers found that daily or weekly supplementation had the greatest benefit for individuals with the utmost substantial vitamin D deficiency (

Source: Adrian R Martineau, et al., “Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data,” BMJ 2017; 356 doi: https://doi.org/10.1136/bmj.i6583

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