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२४ घंटे के व्रत से उम्र संबंधी गैस्ट्रो-इनेस्टिनल और कैंसर की रोकथाम संभव

अमेरिकन संस्था MIT के वैज्ञानिकों ने प्रसिद्ध  शोध पत्रिका “सेल स्टेम सेल” में प्रकाशित अपने शोध में व्रत रखने के वैज्ञानिक लाभों को दर्शाया जो सदियों पुरानी भारतीय व्रत परंपरा  के दूरगामी फायदों की पुष्टि करते हैं | स्टेम कोशिकाएं हम सबके शरीर का महत्वपूर्ण हिस्सा होती हैं, जो विभिन्न अंगो की कोशिकाओं का पुनर्निमाण करती रहती हैं और उनके क्षय को बचाती हैं पर उम्र बढ़ने के साथ उनकी इस क्षमता में कमी आने लगती है जो हमे तमाम बीमारियां का शिकार बनती है। आंत की स्टेम कोशिकाएं भी उम्र बढ़ने के साथ अपनी पुनरुद्ध्भवन या पुनर्निमाण क्षमता धीरे धीरे खोने लगती हैं, जिससे उम्र दराज लोगों की गैस्ट्रो-इनेस्टिनल या अन्य आंत सम्बन्धी बिमारियों जैसे कैंसर इत्यादि से लड़ने की क्षमता कम होती जाती है। अब  वैज्ञानिकों के ग्रुप ने चूहों पर किये प्रयोगों से ये सिद्ध किया है की २४ घंटों का व्रत रखने से आंत की विशिष्ट स्टेम कोशिकाओं की पूनरुद्ध्भवन क्षमता फिर से वापस पायी जा सकती है।

व्रत रखने से उम्र दराज और नवजवान दोनों ग्रुप के चूहों के स्टेम कोशाओं की पुनर्निर्माण क्षमता में आश्चर्यजनक वृद्धि देखी गयी। दरअसल ऐसी स्टेम कोशायें जिन्हे २४ घंटों तक कुछ खाद्य पदार्थ नहीं दिया गया, वे कोशायें ग्लूकोस की बजाये वसीय अम्लों को घटकों में तोड़ने लगीं, जिससे उनकी पुनर्निमाण क्षमता ज्यादा बढ़ गयी।  वैज्ञानिकों ने उम्मीद जताई है की इस तरह का शोध आने वाले समय में उम्र दराज लोग जो गैस्ट्रो-इनेस्टिनल से पीड़ित हैं या जो कैंसर संबंधी कीमोथेरेपी ले रहे हैं, उन लोगों के लिए खास फायदेमंद साबित हो सकती है।




Evolving gene responsible for alcohol digestion may stop Humans from drinking alcohol

A new study by University of Pennsylvania researchers investigating recent signals of positive selection of genes across human populations reveals the concurrent emergence of alcohol dehydrogenase (ADH) gene variant in various populations across the globe without direct genetic heritage. The study has been published in the journal Nature, Ecology & Evolution utilized the 1000 Genome Project data and analyzed 2500 individuals from 20  populations across four continents.

ADH is a group of enzymes normally present in humans to break down the alcohol. But the emergent gene variant of the ADH increases enzyme activity resulting into the less effective breaking down of the alcohol consequently, leading to adverse physical response to alcohol consumption.

People with this specific genetic variant may feel sick after drinking alcohol and henceforth, are unlikely to develop a taste for alcohol or become alcoholic.


Unhealthy Food Cravings are a Sign that Your Body Lacks Minerals!

Next time if you feel intense craving for something supposedly unhealthy like donuts, chocolate, refined carbs or salty snacks, don’t happily eat them since these foods are not going to stop your craving. Surprised to know this fact? Well, the post appeared on TMJ Aid says that Science has found such cravings are a sign that your body is deficient of minerals which may be found in unhealthy foods. However, only minerals from natural sources optimized for great absorption may finally end such cravings, therefore it’s suggested to go for whole foods to stop your cravings as they are much better option.

Source: http://tmjaid.com/unhealthy-food-cravings-are-a-sign-of-mineral-deficiencies/

Vitamin D’s improtance for health in normal life

It is generally accepted (atleast in the west countries) that vitamin D deficiency is a worldwide health problem that affects not only musculoskeletal health but also a wide range of acute and chronic diseases. But, even then in South Asian countries like India and others, physicians or general public is not having full awarenes about the importance of Vit D and Vitamin profiling. Hardly doctors suggest somebody to go for Vitamin profile tests, and mostly people will not have idea that they do have very low Vitamins, specially Vitamin D which is so crucial for all critical diseases. Below is given a little details about Vitamin D, its importance and some mechanism related to.

Vitamin D deficiency has been recognized as a pandemic with a myriad of health consequences. Low vitamin D status has been associated with an increased risk of type 1 diabetes mellitus, cardiovascular disease, certain cancers, cognitive decline, depression, pregnancy complications, autoimmunity, allergy, and even frailty. Low prenatal and neonatal vitamin D status may also increase susceptibility to schizophrenia, type 1 diabetes, and multiple sclerosis (MS) in later life via specific target organ effects, including the immune system, or through epigenetic modification.

Vitamin D (D represents D2, D3, or both) is a secosterol produced endogenously in the skin from sun exposure or obtained from foods that naturally contain vitamin D, including cod liver oil and fatty fish (eg, salmon, mackerel, and tuna); UV-irradiated mushrooms; foods fortified with vitamin D; and supplements.

Despite the many important health benefits of vitamin D, there is controversy regarding the definition of vitamin D deficiency and what the vitamin D requirement should be. In addition, critical windows of exposure to adequate vitamin D levels during fetal maturation remain to be defined owing, in part, to the lack of well-designed controlled clinical trials with long-term follow-up.

Vitamin D (D represents D2, D3, or both) is a secosterol produced endogenously in the skin from sun exposure or obtained from foods that naturally contain vitamin D, including cod liver oil and fatty fish (eg, salmon, mackerel, and tuna); UV-irradiated mushrooms; foods fortified with vitamin D; and supplements.

During exposure to sunlight, 7-dehydrocholesterol (7-DHC) in the skin is converted to previtamin D3. The 7-DHC is present in all the layers of human skin. Approximately 65% of 7-DHC is found in the epidermis, and greater than 95% of the previtamin D3 that is produced is in the viable epidermis and, therefore, cannot be removed from the skin when it is washed. Once previtamin D3 is synthesized in the skin, it can undergo either a photoconversion to lumisterol, tachysterol, and 7-DHC or a heat-induced membrane-enhanced isomerization to vitamin D3. The cutaneous production of previtamin D3 is regulated. Solar photoproducts (tachysterol and lumisterol) inactive on calcium metabolism are produced at times of prolonged exposure to solar UVB radiation, thus preventing sun-induced vitamin D intoxication. Vitamin D3 is also sensitive to solar irradiation and is, thereby, inactivated to suprasterol 1 and 2 and to 5,6-trans-vitamin D3. Cutaneous vitamin D3 production is influenced by skin pigmentation, sunscreen use, time of day, season, latitude, altitude, and air pollution. An increase in the zenith angle of the sun during winter and early morning and late afternoon results in a longer path for the solar UVB photons to travel through the ozone layer, which efficiently absorbs them. This is the explanation for why above and below approximately 33° latitude little if any vitamin D3 is made in the skin during winter. This is also the explanation for why—whether being at the equator and in the far northern and southern regions of the world in summer, where the sun shines almost 24 hours a day—vitamin D3 synthesis occurs only between approximately 10 AM and 3 PM. Similarly, in urban areas, such as Los Angeles, California, and Mexico City, Mexico, where nitrogen dioxide and ozone levels are high, few vitamin D3-producing UVB photons reach the people living in these cities. Similarly, because glass absorbs all UVB radiation, no vitamin D3 is produced in the skin when the skin is exposed to sunlight that passes through glass.

The effect of vitamin D on fetal programming epigenetics and gene regulation could potentially explain why vitamin D has been reported to have such wide-ranging health benefits throughout life.

More details could be accessed from the link of a nicely written review article;

doi:  10.1016/j.mayocp.2013.05.011

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