Good news is here for around 500 million people of mostly developing countries who gets infected with the human whipworm, a potent physical and mental growth damager, now they can be hopeful for effective treatment in coming days as a new finding shows that the whipworm is killed at egg and adult stage by a new drug developed by the team from the three UK universities, Oxford, Manchester and University College London.
Currently there are no vaccines available for human whipworm and treatments are based on ages old drugs having low success rate. The team of researchers studies a class of dihydrobenzoxazepinonesm, which had never been related to regulating whipworms, found the compounds a more effective killer of the adult stages of whipworm than present drugs. Not only that, even whipworm eggs are also affected which are contagious and passed from infected faeces into healthy people by hand to mouth contact, quite often in areas where people live close together or areas with unsanitary toilets.
Generally, the whipworm eggs are highly resistant to UV radiation, extreme temperature changes and may remain viable for longer, however the newly studied compounds which are effective against the eggs could be used as a spray to stop whipworm infection at source itself.
Frederick A. Partridge, Emma A. Murphy, Nicky J. Willis, Carole J. R. Bataille, Ruth Forman, Narinder Heyer-Chauhan, Bruno Marinič, Daniel J. C. Sowood, Graham M. Wynne, Kathryn J. Else, Angela J. Russell, David B. Sattelle. Dihydrobenz[e][1,4] oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo. PLOS Neglected Tropical Diseases, 2017; 11 (2): e0005359 DOI: 10.1371/journal.pntd.0005359