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New Study found Promising Compounds to cure Whipworm infection

Good news is here for around 500 million people of mostly developing countries who gets infected with the human whipworm, a potent physical and mental growth damager, now they can be hopeful for effective treatment in coming days as a new finding shows that the whipworm is killed at egg and adult stage by a new drug developed by the team from the three UK universities, Oxford, Manchester and University College London.

Currently there are no vaccines available for human whipworm and treatments are based on ages old drugs having low success rate. The team of researchers studies a class of dihydrobenzoxazepinonesm, which had never been related to regulating whipworms, found the compounds a more effective killer of the adult stages of whipworm than present drugs. Not only that, even whipworm eggs are also affected which are contagious and passed from infected faeces into healthy people by hand to mouth contact, quite often in areas where people live close together or areas with unsanitary toilets.

Generally, the whipworm eggs are highly resistant to UV radiation, extreme temperature changes and may remain viable for longer, however the newly studied compounds which are effective against the eggs could be used as a spray to stop whipworm infection at source itself.

Source:

Frederick A. Partridge, Emma A. Murphy, Nicky J. Willis, Carole J. R. Bataille, Ruth Forman, Narinder Heyer-Chauhan, Bruno Marinič, Daniel J. C. Sowood, Graham M. Wynne, Kathryn J. Else, Angela J. Russell, David B. Sattelle. Dihydrobenz[e][1,4] oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivoPLOS Neglected Tropical Diseases, 2017; 11 (2): e0005359 DOI: 10.1371/journal.pntd.0005359

https://www.sciencedaily.com/releases/2017/02/170222102540.htm

 

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Unhealthy Food Cravings are a Sign that Your Body Lacks Minerals!

Next time if you feel intense craving for something supposedly unhealthy like donuts, chocolate, refined carbs or salty snacks, don’t happily eat them since these foods are not going to stop your craving. Surprised to know this fact? Well, the post appeared on TMJ Aid says that Science has found such cravings are a sign that your body is deficient of minerals which may be found in unhealthy foods. However, only minerals from natural sources optimized for great absorption may finally end such cravings, therefore it’s suggested to go for whole foods to stop your cravings as they are much better option.

Source: http://tmjaid.com/unhealthy-food-cravings-are-a-sign-of-mineral-deficiencies/

Killing Caner with Genetically modified Bacteria

Researchers employ a genetically modified bacteria to eliminate tumors in mice.

The report published in February issue of the Science Translational Medicine discloses an immunological mechanism that contributes to bacteria-driven, cancer–killing activity claiming that a genetically altered Salmonella typhimurium a gastroenteritis-causing bacteria, is an effective destroyer of mouse tumors.

The reasoning behind most bacteria-driven cancer therapies is the fact that oxygen-starved and necrotic cores of tumors are attractive environments for anaerobic bacteria such as Salmonella, Clostridium, and Listeria, and an infection can lead to tumor colonization by these bugs. By means of active multiplication, the bacteria can directly kill the cancer cells and also attract the attention of the body’s immune system (which is generally suppressed within tumors), leading to further tumor destruction.

Things are not so easy and there are safety issues in implementation for patients. In a recent trial, researchers found attenuated Salmonella bacteria to be safe, but they were unable to create a strong response. To overcome the issue researchers tried to boost the potency of the Salmonella by engineering the bacteria to overexpress a protein proven to induce a strong immune response—flagellin B. As per the new report, intravenous injections of the flagellin expressing Salmonella eliminated the experimental tumors in 55 percent of mice, which then remained healthy until the end of the four-month observation period. Without overexpression of flagellin, the tumors in the mice tended to regrow after initial shrinking by the Salmonella. 

Some scientist agrees that current study extends our understanding of bacterial-based cancer therapy at a molecular level but one of the problems with developing bacterial cancer treatments has been that “these bacteria are almost a black box.” They promote cancer destruction, but no one is exactly sure how.

Source: J.H. Zheng et al., “Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin,” Science Translational Medicine, 9, eaak9537, 2017.

Take Vitamin D regularly to keep away from Respiratory Diseases

vit-d-images

Next time if you suffer with acute respiratory infections, don’t ignore your Vitamin D status which plays a significantly effective role in prevention from respiratory diseases, claimed by a new research paper published online in journal the BMJ. The study confirms that daily or weekly vitamin D supplements had the utmost advantage for individuals with the maximum noteworthy vitamin D deficiency.

Generally, people comprehend that vitamin D is critical for bone and muscle health but this new research found that it also helps the body fight acute respiratory infection, which is accountable for millions of deaths globally each year. The new research is a global collaborative study comprising a participant data meta-analysis of 25 randomized controlled trials including >11,000 participants.

Many observational studies have already established the association of low vitamin D levels with greater vulnerability to acute respiratory infections, based on long time follow up of participants without providing a specific treatment. There have been discrepancies in clinical trials conducted to investigate the protective ability of vitamin D supplementation.

The new study resolves these inconsistencies and the researchers found that daily or weekly supplementation had the greatest benefit for individuals with the utmost substantial vitamin D deficiency (

Source: Adrian R Martineau, et al., “Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data,” BMJ 2017; 356 doi: https://doi.org/10.1136/bmj.i6583

Thank our fruit-hunting ancestors for the color vision in Humans

Humans with red-green color blindness, see a different spectrum blame it to the dichromacy (two types of cone cells) rather than trichromacy (three types of cone cells) in normal Humans. Have you ever imagined what would have happened if we had not been blessed with trichromatic vision and how we developed this, thank our fruit-hunting ancestors, claimed by a report shown at the annual meeting of AAAS, which publishes Science.

Few of the primate species (our early ancestors) have three different types of light-sensitive cone cell in eyes (trichromacy) rather than two which makes primate exceptional and allows humans to explore what we think of as the standard spectrum of color. As per the hypothesis, the satandard explanation for trichromacy in primates, is that it allowed them to see colourful ripe fruit more easily against a mostly green background of the forest. The rhesus macaque (a particular Old World monkey), has a genetic discrepancy to offer a convenient natural test of this hypothesis. A common mutation makes some females have three types of cone cells whereas others having two only. Based on a study report including >20000 individual observations of 80 different macaques feeding from 30 species of trees on Cayo Santiago, Puerto Rico, researchers can say with some confidence that wild trichromatic female monkeys do certainly seem to trace and eat fruit quicker than dichromatic females monkeys, leading strong support to the idea that this differentiating advantage of trichromacy over dichromacy helped drive the evolution of trichromacy in Humans and other relatives.

Source: http://www.sciencemag.org/news/2017/02/you-can-thank-your-fruit-hunting-ancestors-your-color-vision

MERS could be curable..Antibody against MERS found by Scientists

MERSinfographic

A team of Scientists have recognized a protein that worn out the MERS virus, giving the hope for a potential relief to prevent and treat the incurable disease, according to a report published in Proceedings of the National Academy of Sciences on 27th July. Middle East Respiratory Syndrome (MERS) is an exceptionally lethal pulmonary infection instigated by a formerly unidentified coronavirus (CoV), possibly passed on to humans by infected camels. There is no licensed vaccine or antiviral available so far to treat MERS, which causes symptoms such as fever, cough and shortness of breath. The team isolated a potent MERS-CoV-neutralizing antibody, named LCA60, from memory B cells of an infected patient. LCA60 antibody binds to a novel site on the spike protein and effectively nullifies infection of MERS by meddling with the binding to the cellular receptor CD26. Scientists claim that LCA60 antibody can efficiently be used for prophylaxis, for postexposure prophylaxis of individuals at risk, or for the treatment of human cases of MERS infection. Notably, LCA60, when given to infected mice, dramatically reduced the amount of the MERS virus in the lungs within days. Even in the worst-case scenario, only one virus remained after three days for every 100 viruses at the start of the treatment. In most cases, the virus became untraceable within five days of treatment. The antibody fought the virus whether it was given a day before or a day after the mice were infected. Current MERS outbreak in China and South Korea has caused 186 infections and 36 deaths as of 28th July WHO report.

See in details;

D. Corti et al. Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus. PNAS. Published online July 27, 2015. doi: 10.1073/pnas.151019912

Autism could be detected by smell test

Doctors may sniff out autism with a 1o minute test, says a new study.

sniff test

According to researchers report of July 2 in Current Biology, children with autism inhale almost same amount of air whether smelling sour milk or roses whereas, kids without the disorder breathe in pleasant scents more deeply than stinky ones.

The findings hint that a whiff-and-sniff test could one day offer a quick and easy way to determine whether a child has autism. But the study was small, and other researchers are not convinced.

source

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